For decades, the relationship between testosterone therapy (TRT) and prostate cancer has been clouded by caution, fear, and outdated beliefs. But emerging science is changing the conversation—and offering new hope to men who want to reclaim vitality, strength, and quality of life after prostate cancer treatment.

A major breakthrough study by José Flores and colleagues has delivered exciting news: men who received testosterone therapy after prostatectomy did not experience a higher risk of cancer recurrence compared to those who didn’t receive TRT. In fact, the biochemical recurrence (BCR) rate in both groups was approximately 2% over a five-year follow-up period—a powerful indication that testosterone replacement therapy may be safe in well-selected prostate cancer survivors.

What This Means for Men After Prostate Cancer

If you’re one of the millions of men struggling with low testosterone following prostate cancer surgery, you’ve likely been told that TRT is off the table. For years, the prevailing belief was that testosterone “feeds” prostate cancer—leading many physicians to avoid it altogether.

But science is evolving, and so is our understanding of hormone health. This robust study, involving a large cohort of post-prostatectomy patients, tells a more nuanced and encouraging story: carefully monitored testosterone therapy does not appear to increase recurrence risk in men with treated prostate cancer.

Why This Study Matters

• Long-term data: With a follow-up period of five years, this study gives us a meaningful look at the safety of TRT over time.

• Low recurrence rate: The 2% BCR rate was virtually the same in both TRT users and non-users, suggesting no added risk from testosterone therapy.

• Larger sample size: Unlike earlier, smaller studies, this research adds a critical layer of credibility by including a broad and diverse patient population.

At Hormone Health and Wellness of the Palm Beaches, we’re committed to evidence-based care. This study validates what many hormone specialists have been observing in clinical practice: when testosterone is prescribed responsibly, it can be a game-changer for men’s physical, mental, and sexual health—even after prostate cancer.

Our Approach: Precision, Safety, and Personalization

Every man’s health journey is unique. That’s why we take a personalized approach to hormone replacement therapy, especially for men with a history of prostate cancer. At our clinic, we would, with your approval, work with your urologist and monitor all critical biomarkers—including PSA—throughout your treatment.

We believe in balancing safety with the quality of life you deserve. If you’re experiencing fatigue, low libido, muscle loss, depression, or cognitive fog following prostatectomy, you don’t have to accept these symptoms as “the new normal.”

The Bottom Line

This landmark study from José Flores et al. adds to a growing body of research suggesting that testosterone therapy can be both safe and effective for select men post-prostatectomy. It’s time to move past fear and start making informed, empowered choices about hormone health.

If you’re ready to explore whether TRT is right for you, contact us today at Hormone Health and Wellness of the Palm Beaches. Our expert team is here to guide you every step of the way with compassion, clinical excellence, and a commitment to your wellness.

Cheers,
Dr. Curt Mondell PhD